Yellowfin have some natural predators including sharks and large bony fish.
The most serious threat to yellowfin tuna is the commercial fishery. This species is a popular target and the mode of catch (purse seine) can capture huge schools at a time. In the U.S., yellowfin tuna is one of the primary fish for canned consumption.
The tuna fishery has long been controversial for its high rates of dolphin bycatch; however, regulation has improved adverse impacts to dolphins.
Yellowfin are also sport-fished in southern California, Baja, Mexico, Hawaii, and along the southeastern U.S. including the Gulf of Mexico.